Turnkey Smart Multiwell Plates

The TNO solution is a platform technology that can manufacture well plates for microphysiological systems, with the same footprint as a standard ANSI/SLAS wellplate. TNO leverages a scalable technology that has already proven effective globally for Flat Panel Display (FPD) manufacturing. The same manufacturing principles are used to integrate advanced functionalities and features such as microfluidics, biosensors, membranes and micropatterns, all essential to OoC technologies. Various combinations of these features and functionalities are needed for each specific use context. TNO can therefore develop customised, fit-for-purpose Turnkey Smart Multiwell Plates equipped with the functionalities companies need for their specific application.

TNO’s experience in OoC technologies, biomedical engineering, translational biology, industrial upscaling and regulatory NAM frameworks were essential to the development of a solution that addresses drug developers’ key challenges. The standardised ANSI/SLAS compatibility enables direct integration into existing lab infrastructure. Integrated microfluidics, membranes and sensors improve physiological relevance and robustness and enables real-time monitoring. And the scalable, flexible  FPD-based manufacturing reduces costs per well plate and allows different well plate designs to be bundled on one substrate, which enables lower entry point costs, even in high-mix, low-volume production scenarios.

The Turnkey Smart Multiwell Plate is among the first concepts to translate FPD manufacturing into a fully standardised, multiwell plate-compatible OoC platform. Bundling multiple application-specific designs on a single substrate and using foundry-based production models is also a novel approach for OoC technologies. Unlike existing OoC devices, the plate enables scalable mass production and plug-and-play lab compatibility.

Each fit-for-purpose Turnkey Smart Multiwell Plate enables more robust and human-relevant in vitro testing in a single platform. The system improves drug screening by enhancing in vitro-in vivo correlation. TNO’s solution offers the pharmaceutical, food, chemical, and cosmetic industry the opportunity to make early, well-informed decisions with less disruption. It reduces adoption barriers and improves alignment with regulatory NAM frameworks, all while maintaining usability within a standard laboratory infrastructure.

Pharmaceutical and biotech companies will undoubtedly benefit from this scalable, smart, and easy-to-implement solution. Through faster, more accurate drug development and reduced development costs, these partners will gain and maintain a competitive edge. Yet benefits also apply to academic researchers and the chemical, cosmetic, and food safety industries, who can also apply the technology to accelerate and scale their testing capabilities. In the end, society as a whole will benefit most, as drugs are developed faster, animal testing is reduced, and patient outcomes improve.

Could Turnkey Smart Multiwell Plates technology benefit your market position? Contact us for investment and/or development opportunities.